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INSPRA® (eplerenone) Contraindications


For All Patients

INSPRA is contraindicated in all patients with:

  • serum potassium >5.5 mEq/L at initiation,
  • creatinine clearance ≤30 mL/min, or
  • concomitant administration of strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir) [see Drug Interactions (7.1), Clinical Pharmacology (12.3)].

For Patients Treated for Hypertension

INSPRA is contraindicated for the treatment of hypertension in patients with:

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